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Pick your subject.Matthew 22 Jesus( YAHushua) 37 And he said to him, “You shall love the Lord your God with all your heart and with all your soul and with all your mind. 38 This is the great and first commandment. 39 And a second is like it: You shall love your neighbor as yourself.
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| 238.SYNAGOGUE OF SATAN | 239.PATRIOT ACT? | 240.WHY WE ARE HERE? | 241.VACCINATION HIDDEN TR... | 242.CHRIST TEACHINGS | 243.POISON MONEY AND RECE... | 244.BUIDING 7 | 245.9-11 TRUTHERS DEAD? | 246.GREAT SPEECHES | 247.GODUANDME! | 248.911 IN PLANE SITE | 249.THE N.W.O PLAN? | 250.BRAIN ON DRUG | 251.LOVE THY ENEMY | 252.JOHN TODD | 253.YOU PICK | 254..US????? | 255.TRUTH ANONYMOUS? | 256.CHRIST CHANGE | 257.NAME OF CHRIST! | 258.WHAT THEY WANT | 259.PROTEST | 260.OCCULT IN DETRIOT | 261.ATTRIBUTES OF GOD | 262.SCHOOLS AND PRISONS? | 263.DARK AGENDA | 264.OBAMA'S RELIGION? | 265.YOUR THOUGHTS | 266.SATURN = SATAN | 267.THE BIG PICTURE | 268..ALL YOU CAN | 269.ILLUMINATI COLOR | 270.MESSAGE ME | 271.THE ULTIMATE CON | 272.MATRIX  | 273.MOTHER OF SECRET | 274.CATHOLICISM | 275.U.S. MEAT TREATED | 276.HELIOCENTRIC | 277.KNOW YOUR ENEMY | 278.LIES | 279.GA GA MARRY THE.. | 280.MEDIA LIES EXPOSED | 281.LUCIFER IN THE BIBLE | 282.EYES WIDE SHUT | 283.2012 | 284.DIEING TEEN LOVES GOD | 285.ARRIVAL OF THE ANTCHR... | 286.ALICE IN THE WHITEHOU... | 287.KHAZARIAN CONSPIRACY? | 288.WHERE IS THE CHANGE? | 289.RON PAUL | 290.ROMAN EMPIRE RULES TO... | 291.WHITE HAIRED PRESIDEN... | 292.SOPA WIL KILL THE INT... | 293.YOU CHOOSE | 294.ALIEN TRANSMISSION? | 295.BIBLE AND DRUGS | 296.THE RIGHT GROUP | 297.THE APOSTLE PAUL  | 298.SIN | 299.MEDIA BUSTED AGAIN | 300.SATANIC SUPERBOWL | 301.6TH PYRAMID? | 302.STARS,DRUGS AND DEATH | 303.NEW BARCODE | 304.SPAM | 305.GIRL SCOUT COOKIES | 306.JUSTIN BIEBER SATANIC... | 307.QUESTIONS TO GOD | 308.NO ABORTIONS! | 309.DEAD FETUS IN PRODUCT... | 310.666 PLANNED PARENTHOO... | 311.SINGULAR TIME | 312.REPTLIAN DEMON | 313.FEEDING THE HOMELESS ... | 314.NO JEHOVAH'S WITNESSE... | 315.TWILIGHT ZONE EXPOSED... | 316.YAHOO VS YAH | 317.BREAKING DOWN TIME |  318.EX VOODOO PRIEST | 319.THINGS NOT TO SAY? | 320.RESURECTION DAY! | 321.MUSIC NOTE | 322.WATER | 324. MOST THING WE DON'T ... | 325.WORLD CHURCH CORRUPTE... | 326.ILLUMINATI NOT A MYTH... | 327.SATANIC PRODUCTS? | 328.NAZI CONSPIRACY  | 329.TRUTHSPIRITSEE | 330.STAR WARS CULT! | 331.THE VOICE | 332.ANGEL WARS | 333.MASON | 334.JEM  | 335.YAHUSHUA JESUS CHRIST | 336.GOOD HEALTH | 337.N.W.O DRONES | 338.WHISTLEBLOWERS | 339.SATANS WORDS! | 340.WHAT THEY CALL US! | 341.MASON LOGO BUSTED! | 342.SKULLS MEN  | 343.T.S.A PICS | 344.DONT TREAD ON ME!? | 345.LEGAL DISCLAIMER | 346.POSSESSED STAR | 347.FACEBOOK BIG BROTHER | 348.VIPER GROUPS | 349.FREEDOM | 350.WHAT'S IN CHEMTRAILS | 351.DEAD SCIENTIST  | 352.ALEX JONES IS A SHILL | 353.BUCKINGHAM PALACE SAT... | 354.EXTRFEMETRUTHTALKRADI... | 355.SATANIC NOTE | 356.GOOD DOG | 357.APPLE'S INSIDES | 358.COLORADO FIRE SPIRITS | 359. A PRAYER THESE DAYS | 360.THE CRUSADERS | 361.WEB BROWSERS BUSTED | 362.NAZI POPE | 363.9/11 MORE BELIEVABLE  | 364.GENPETS | 365.MASON'S BUSTED AGAIN | 366.CLONING | 367.CANCER FIGHTERS | 368.COLORADO SHOOTING LIN... | 369.BLOOD SACRIFICE! | 370.STAR SOLSTICE SACRIFI... | 371.WHY ARE THEY SPRAYING... | 372.BEST ONLINE BIBLE | 373.FOOTBALL SEASON MIND ... | 374.AMERICAS GOT TALENT | 375.XXX = 666 | 376.9/11/01 ''FLIPPED'' | 377.911 CROSS | 378.HORUS LIE | 379.WEDDING FINGER | 380.OFF BUTTON IS REPTILI... | 381.911- ON THE MONEY | 382.NEW WORLD SOCIETIES! | 383.KUNDALINI DECEPTION | 384.ROSARY DECEPTION! | 385.VATICAIN  SYMBOLOGY | 386.ATHEIST DECEPTION | 387.VATICAN FLAG BUSTED | 388.ALBERT PIKE  | 389.DARK MATTER CARTOON | 390. USB  | 391.ANCIENT ALIENS BUSTED | 392.COLUMBUS DAY  | 393.LUCIFER TELSCOPE  | 394. 666 | 395.GENDER LOGO | 396.STARS WARS DEMONS | 397.TOYS ''R''US | 398. MORMON CULT | 399.PAC MAN | 400. PRESIDENTIAL DEBATE ... | 401.NAME OF JESUS | 402. PRESIDENTIAL ELECTIO... | 403.UNCLE SAM SCAM! | 404.G.M.O | 405.DONKEY | 406.THE V MASK IS THE DEV... | 407. BURIED ALIVE | 408.WWW=666 | 409.GOOGLE BUSTED | 410.MARGARIN | 411.DON'T TEXT AND DRIVE | 412.AZTEC MAYAN TABLET 20... | 413.MOON HAS SATAN'S IMAG... | 414. CONNECTICUT SCHOOL S... | 415.DRUGED KILLERS | 416.ILUMINATI HIP HOP 101 | 417.DEMON DREAM MINPULATI... | 418.OUT OF THE DEVIL | 419.SO CALLED TRUTH MOVEM... | 420.VATCAN CHRISTMAS! | 421.RAPE INVESTIGATION | 422.VIRGIN MARY DECEPTION | 423. CENSORING EXTREMELIF... | 424.YOUTUBE CENSORED ME! | 425.FACEBOOK CENSORED ME! | 426.SATANIC STAR | 427. HOLLYWOOD DEMONS | 428.WHAT SCARES THE DEVIL... | 429.AMERICAN'S GREAT SEAL... | 430.STAGES OF TRUTH | 431.F.B.I LOGO | 432. ISRAEL ON THE MIND | 433.SUPER BOWL BUSTED/ BE... | 434. 2013 CHINESE SNAKE Y... | 435.BODY ILLUMINATION | 436.CNN DECEPTION! | 437. BIRTH CERTIFICATE OW... | 438.CANADIAN SATAN | 439.OSCAR | 440. ILLUMINATI TITANIC | 441.AVATAR | 442.HISTORY CHANNEL | 443. GEORGE C COMEDIAN | 444.TOXIC INGREDIENTS | 445.PEACE SIGN /UPSIDE CR... | 446.HAND PEACE  SIGN! | 447. HAND PYRAMID | 448.HOLLY WOOD? | 449.QUEEN AND HER NURSE  | 450.NEW POPE 3/3/13 | 451.TANNING BED CANCERS | 452.WWE ILLUMINATI | 453.NIKE IS ILUMINATI | 454.OLD MEANINGS | 455.MASON G =GATE | 456.POISON POP | 457.E.M.F DANGER! | 458.RAP HISTORY | 459.JOE ROGAN SHILL | 460.D.M.T | 461.LAMININ  | 462.MARLBRO MAN | 463.AMERICA LOOKS LIKE A ... | 464.BOSTON BOMBING | 465.NATRUAL ALTERNATIVES | 467.EURO MARK PORTAL | 468. PENTAGON IS A PENTAG... | 469. NEW TRADE CENTER | 470.PARAMONT INTRO EVIL | 471.MONSANTO | 472.9-11 P.A SET UP | 473.DONATE TOO ILLUMINATI... | 474.WAR | 475. BUDWEISER | 476. MAGNESIUM MIRCLE | 467.4TH OF JULY | 468.GOOGLE ANDROID PHONE | 469.FEET AND EVOLUTION | 470.GOOGLE FACE | 471.GOOGLE DOODLE DECODED | 472.ROYAL BABY | 473.THEY AND YOU | 474. REPEL BUGS | 475.DIABLO HANDS | 476.DEMON HYBRID! | 477.GREEK NUMBER 666 | 478.ILLUMINATI FLAGS! | 479 CHEMTRIALS FOR DECADE... | 480.YAHOO'S NEW LOGO | 481. NEANDERTHALS | 482.HOLLYWOOD SLAVES | 482.THE BUTLER  | 483.BAT VS SUPERMAN | 484.MTV SATANIC 2013  | 485. BRITISH FLAG 666 | 486.MIND CONTROL TV! | 487.ILLUMINATI WAR MACHIN... | 488.JOHN KERRY | 489.MARK                 ... | 490.SONNY TRUTHER | 491.MORE LAW LESS FREEDOM | 492.CASTING COUCH | 493.WORLD MAP IS WRONG | 494.STOP CHEMTRAILS | 495.WHO CONTROLS THE U.N | 496.THEY LIVE WAS A DOC! | 497. EYE OF RA | 498.JOEL OLSTEN NEW AGE | 499.FED AND THE 2 PRESIDE... | 500.GREAT LAKES ARE DEMON... | 501. DEMONS IN THE WORLD ... | 502. SATANIC HALLOWEEN | 503.ALIENS ON THE DOLLAR | 504.NATO CONTROLS U.S MIL... | 505.HISTORY OF THE N.W.O | 506.FREE ENERGY STOPPED | 507.NEW 100 DOLLAR BILL | 508.CANADIEN'S FLAG IS A ... | 509.JFK ASSASSINATION | 510.TWITTER LOGO DECODED! | 511.NELSON MANDELA SHILL | 512.SANDY HOOK AND THE SU... | 513.FACEBOOK APP SPIES | 514.FACEBOOK LOGO DECODED... | 515.SATAN AND SANTA | 516.MEANING OF CHRISTMAS | 517.THE ROCK AND THE  ILL... | 518.GREAT IDEAS | 519.DEATH STAR REPTILIAN | 520.DOLLAR BILL LATIN WOR... | 521.DECEPTION OF A GENERA... | 522.BAPHOMET | 523.LOL  MEANING | 524.HARRY POTTER SATANIC | 525.SATAN ON THE DIME | 526.WIZARD OF OZ IS A DEM... | 527.MATRIX DECODED | 528.OLIVE GARDEN LOGO BUS... | 529. JUSTIN BIEBER'S TATT... | 530.SATANIC GRAMMYS 2014 | 531.YODA DEMON | 532.SATANIC SUPER BOWL | 533. OLYMPICS ALIENS | 534.MAY 1ST ILLUMINATI | 535.THE BRAIN SPLIT | 536.FORD 666 | 537.OCCULT OLYMPICS | 538.KATY PERRY SELLS HER ... | 539.NEW WORLD ORDER/OCCUL... | 54O.BAPHOMET ON OSCARS ST... | 541.DAYLIGHT SAVING TIME ... | 542.PROJECT CLOVERLEAF/CH... | 543.AMERICAN FEMA CAMPS | 544.DOLAR BILL 666 | 545.ILLUMINATI IS REAL | 546.MECA AND THE BEAST | 547.ST.PATTY DAY | 548.GOD FACTS | 549.BAPHOMET ON THE DOLLA... | 550.SOCIAL SECURITY CARD ... | 551.GODZILLA AND FUKUSHIM... | 552.SOCHI OLYMPICS ALIENS | 553.GROUNDED! | 544.OSAMA AND THE CIA | 545.CATHOLIC HAND CROSS  | 556.WHAT IS IN CHEMTRAILS | 557.U.N ADMITS SPRAYING C... | 558.ILLUMINATI MAPS | 559.ILLUMINATI PAGAN HOLI... | 560.YOU DON'T PICK THE PR... | 561. NOT A COINCIDENCE | 562.BILL COPPER A SHILL? | 563.STAR OF DAVID DECEPTI... | 564.EASTER VS RESURRECTIO... | 565.WWE/WWF ILLUMINATI PE... | 566.RONALD MCDONALD 666  | 567.ALIEN DECEIT | 568.MEDICAL SNAKE STAFF | 569. SATANIC MONUMENT USA | 570.BRITISH FILM AWARDS I... | 571.DOLLAR BILL DEMON | 572.FEEMASONS WORSHIPING ... | 573.LIGHTNING BOLT SYMBOL... | 574. NASA NAZIS. | 575.MICHAEL JACKSON'S HOL... | 576.FRUIT OF THE LOOM DEM... | 577.EDWARD SNOWDEN IS A F... | 578.SIMILARITIES? | 579.SANTA BARBRA SHOOTING... | 580.NASA WAR DOCUMENT vs ... | 581.HASH TAG # MEANING | 582.OBAMA FLASHES EL DIAB... | 583. TATTOOS AND THE BIBL... | 584.WAR ON TERROR WAS NEV... | 585.STARBUCKS ILLUMINATI | 586.DOLLAR BILL EXPLAINED | 587.WHERE IS THE BOING 74... | 588.REVELATIONS REVEALED | 589.SIMPSONS ILLUMINATI/S... | 590.FIFA WORLD CUP AND SA... | 591.THE MEANING OF INDEPE... | 592.UNITED STATES SEAL DE... | 593.FIFA'S WORLD CUP  TRO... | 594.THE ILLUMINATI AND LE... | 595.UNIVISION LOGO DECODE... | 596.E.M.F WAVES | 597.ILLUMINATI WEIRD AL Y... | 598.GMOS SEEDS OF POSION | 599.CHEMTRAILS/GEO ENGINE... | 6OO.ILLUMINATI LIST OF CO... | 601.MOVIE LOGOS DECODED | 602. FALSE DOCTRINES | 603.AMERICAN FLAG AND OCC... | 604.WINDOW 7 IS A NATZI L... | 605.ICE BUCKET CHALLENGE | 606.THE WORLD SYSTEM | 607.ILLUMINATI INTERVIEW ... | 608.BAPHOMET EXPOSED | 609.OBAMA 9/10/14 SPEACH ... | 610.ILLUMINATI AND DORITO... | 611.CHURCH OF SATAN IN SC... | 612.APPLE AND  I PHONE EX... | 613.CIA ASSASSIN GUN | 614.AIDS AND EBOLA ARE MA... | 615.TRUTHER APP | 616.CONSPIRACY THEORIST M... |

MONEY AS WE KNOW IS ONE OF THE DIRTIES THINGS YOU CAN TOUCH NOW IT CAN HARM YOU!

ARE MONEY AND RECEIPTS ARE POISON!
Do your research!
Study finds bisphenol A on money 
A new report says Bisphenol A (BPA), the controversial hormone disrupting chemical widely used in plastics, is turning up in an unlikely place--the money in your wallet.

Researchers suggest that BPA is rubbing off cashier receipts and onto bills, according to a report titled "On The Money: BPA on Dollar Bills and Receipts," published by the Safer Chemicals, Healthy Families, and the Washington Toxics Coalition (WTC).

Lab tests confirm the chemical rubs off receipts onto the skin after holding it for just 10 seconds. WTC researchers first tested 22 thermal paper receipts collected from businesses in 10 states and the District of Columbia. Half contained higher than trace amounts of BPA. 

They also tested 22 $1 bills and found BPA on 21 of them. Schreder says contamination most likely occurs once receipts come in contact with money in places like wallets and cash register drawers.

"Levels on dollar bills were lower than on receipts, but the fact that our currency is contaminated with a hormone-disrupting chemical illustrates how our current chemical law is failing us," Schreder says. "Even the most careful consumer can't avoid BPA when it's so pervasive that it even contaminates money."

In July, The Environmental Working Group released a similar study about BPA and cash register receipts. EWG researchers tested 36 and found 40 percent had high levels of the chemical.

Environmental groups and public health advocates have linked BPA to a number of serious health problems including cancer, diabetes, infertility, early puberty and heart disease. According to the National Institute of Health (NIH), 93 percent of urine samples from people over the age of 6 have detectable levels of BPA.

Earlier this year the FDA said recent studies "provide reason for some concern about the potential effects of BPA on the brain, behavior, and prostate gland of fetuses, infants and children."

"We need to update the 1976 Toxic Substances Control Act with a new chemical law that both requires companies to provide health information on chemicals they produce and ensures that chemicals that can cause cancer, infertility, and other health problems can't be used in everyday products."
God has a hard time getting us to pay attention! We work hard, we play hard, cram a million things into a week & weekends. We arent seeing the Train coming around the corner! How can He wake us up, except by shocking us into it!?....Mans everlasting Ignorance is the principle of "Condemnation before Investigation". 
"The calcite in otoconia has been shown to exhibit piezoelectricity." "If piezoelectricity were to exist [in the pineal calcite microcrystals], an electromechanical coupling mechanism to external electromagnetic fields may be possible."

Click below to find more information on this toxic substance and the harm that it does to us!

Bisphenol A - Wikipedia, the free encyclopedia



Bisphenol A, commonly abbreviated as BPA, is an organic compound with two phenol functional groups. It is used to makepolycarbonate plastic and epoxy resins, along with other applications.

Known to be estrogenic since the mid 1930s, concerns about the use of bisphenol A in consumer products were regularly reported in the news media in 2008 after several governments issued reports questioning its safety, prompting some retailers to remove products containing it from their shelves. A 2010 report from the United States Food and Drug Administration (FDA) raised further concerns regarding exposure of fetuses, infants and young children.[1] In September 2010, Canada became the first country to declare BPA as a toxic substance.[2][3] In the European Union and Canada, BPA use is banned in baby bottles.[4]

 

Health effects

Bisphenol A is an endocrine disruptor, which can mimic the body's own hormones and may lead to negative health effects.[27][28][29][30] Early development appears to be the period of greatest sensitivity to its effects,[31] and some studies have linked prenatal exposure to later neurological difficulties. Regulatory bodies have determined safety levels for humans, but those safety levels are currently being questioned or under review as a result of new scientific studies.[32][33] A 2011 study that investigated the number of chemicals to which pregnant women in the U.S. are exposed found BPA in 96% of women.[34]

In 2009, The Endocrine Society released a statement expressing concern over current human exposure to BPA.[35]

In 2011, the Food Standards Agency's chief scientist said "the evidence [is] that BPA is rapidly absorbed, detoxified, and eliminated from humans – therefore is not a health concern."[36]

[edit]Expert panel conclusions

In 2007, a consensus statement by 38 experts on bisphenol A concluded that average levels in people are above those that cause harm to many animals in laboratory experiments. However, they noted that while BPA is not persistent in the environment or in humans, biomonitoring surveys indicate that exposure is continuous, which is problematic because acute animal exposure studies are used to estimate daily human exposure to BPA, and no studies that had examined BPA pharmacokinetics in animal models had followed continuous low level exposures. They added that measurement of BPA levels in serum and other body fluids suggests that either BPA intake is much higher than accounted for, or that BPA can bioaccumulate in some conditions such as pregnancy, or both.[37] A 2011 study, the first to examine BPA in a continuous low level exposure throughout the day, did find an increased absorption and accumulation of BPA in the blood of mice.[38]

In 2007 it was reported that among government-funded BPA experiments on lab animals and tissues, 153 found adverse effects and 14 did not, whereas all 13 studies funded by chemical corporations reported no harm. The studies indicating harm reported a variety of deleterious effects in rodent offspring exposed in the womb: abnormal weight gain, insulin resistance, prostate cancer, and excessive mammary gland development.[39]

A panel convened by the U.S. National Institutes of Health in 2007 determined that there was "some concern" about BPA's effects on fetal and infant brain development and behavior.[7] The concern over the effect of BPA on infants was also heightened by the fact that infants and children are estimated to have the highest daily intake of BPA.[40] A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing "some concern for effects on the brain, behavior, and prostate gland in fetuses, infants, and children at current human exposures to bisphenol A," and "minimal concern for effects on the mammary gland and an earlier age for puberty for females in fetuses, infants, and children at current human exposures to bisphenol A." The NTP had "negligible concern that exposure of pregnant women to bisphenol A will result in fetal or neonatal mortality, birth defects, or reduced birth weight and growth in their offspring."[41]

[edit]Obesity

A 2008 review has concluded that obesity may be increased as a function of BPA exposure, which "merits concern among scientists and public health officials".[42] A 2009 review of available studies has concluded that "perinatal BPA exposure acts to exert persistent effects on body weight and adiposity".[43] Another 2009 review has concluded that "Eliminating exposures to (BPA) and improving nutrition during development offer the potential for reducing obesity and associated diseases".[44] Other reviews have come with similar conclusions.[45][46] A later study on rats has suggested that perinatal exposure to drinking water containing 1 mg/L of BPA increased adipogenesis in females at weaning.[47] Other study suggested that larger size-for-age was due to a faster growth rate rather than obesity[48]

[edit]Neurological issues

A panel convened by the U.S. National Institutes of Health determined that there was "some concern" about BPA's effects on fetal and infant brain development and behavior.[7] A 2008 report by the U.S. National Toxicology Program (NTP) later agreed with the panel, expressing "some concern for effects on the brain".[41] In January 2010 the FDA expressed the same level of concern.

A 2007 review has concluded that BPA, like other xenoestrogens, should be considered as a player within the nervous system that can regulate or alter its functions through multiple pathways.[49] A 2007 review has concluded that low doses of BPA during development have persistent effects on brain structure, function and behavior in rats and mice.[50] A 2008 review concluded that low-dose BPA maternal exposure causes long-term consequences at the level of neurobehavioral development in mice.[51] A 2008 review has concluded that neonatal exposure to Bisphenol-A (BPA) can affect sexually dimorphic brain morphology and neuronal adult phenotypes in mice.[52] A 2008 review has concluded that BPA altered long-term potentiation in the hippocampus and even nanomolar dosage could induce significant effects on memory processes.[53] A 2009 review raised concerns about BPA effect on anteroventral periventricular nucleus.[54]

A 2008 study by the Yale School of Medicine demonstrated that adverse neurological effects occur in non-human primates regularly exposed to bisphenol A at levels equal to the United States Environmental Protection Agency's (EPA) maximum safe dose of 50 µg/kg/day.[55][56] This research found a connection between BPA and interference with brain cell connections vital to memory, learning and mood.

A 2010 study with rats prenatally exposed to 40 microg/kg bw BPA has concluded that corticosterone and its actions in the brain are sensitive to the programming effects of BPA.[57]

[edit]Disruption of the dopaminergic system

A 2005 review concluded that prenatal and neonatal exposure to BPA in mice can potentiate the central dopaminergic systems, resulting in the supersensitivity to the drugs-of-abuse-induced reward effects and hyperlocomotion.[58]

A 2008 review has concluded that BPA mimics estrogenic activity and impacts various dopaminergic processes to enhance mesolimbic dopamine activity resulting in hyperactivity, attention deficits, and a heightened sensitivity to drugs of abuse.[59]

A 2009 study on rats has concluded that prenatal and neonatal exposure to low-dose BPA causes deficits in development at dorsolateral striatum via altering the function of dopaminergic receptors.[60] Another 2009 study has found associated changes in the dopaminergic system.[61]

[edit]Thyroid function

A 2007 review has concluded that bisphenol-A has been shown to bind to thyroid hormone receptor and perhaps have selective effects on its functions.[62]

A 2009 review about environmental chemicals and thyroid function, raised concerns about BPA effects on triiodothyronine and concluded that "available evidence suggests that governing agencies need to regulate the use of thyroid-disrupting chemicals, particularly as such uses relate exposures of pregnant women, neonates and small children to the agents".[63]

A 2009 review summarized BPA adverse effects on thyroid hormone action.[64]

[edit]Cancer research

According to the WHO's INFOSAN, "animal studies have not provided convincing evidence of risk of cancer from BPA exposure."[65]

Neither the U.S. Environmental Protection Agency[66] nor the International Agency for Research on Cancer[67] has evaluated bisphenol A for possible carcinogenic activity.

A 2010 review at Tufts University Medical School concluded that Bisphenol A may increase cancer risk.[68]

[edit]Breast cancer

A 2008 review has concluded that "perinatal exposure to (...) low doses of (..) BPA, alters breast development and increases breast cancer risk".[69] Another 2008 review concluded that "animal experiments and epidemiological data strengthen the hypothesis that fetal exposure to xenoestrogens may be an underlying cause of the increased incidence of breast cancer observed over the last 50 years".[70]

A 2009 in vitro study has concluded that BPA is able to induce neoplastic transformation in human breast epithelial cells.[71] Another 2009 study concluded that maternal oral exposure to low concentrations of BPA during lactation increases mammary carcinogenesis in a rodent model.[72]

A 2010 study with the mammary glands of the offspring of pregnant rats treated orally with 0, 25 or 250 µg BPA/kg body weight has found that key proteins involved in signaling pathways such as cellular proliferation were regulated at the protein level by BPA.[73]

A 2010 study has found that BPA may reduce sensitivity to chemotherapy treatment of specific tumors.[74]

[edit]Neuroblastoma

In vitro studies have suggested that BPA can promote the growth of neuroblastoma cells.[75][76] A 2010 in vitro study has concluded that BPA potently promote invasion andmetastasis of neuroblastoma cells through overexpression of MMP-2 and MMP-9 as well as downregulation of TIMP2.[77]

[edit]Prostate development and cancer

A 1997 study in mice has found that neonatal BPA exposure of 2 μg/kg increased adult prostate weight.[78] A 2005 study in mice has found that neonatal BPA exposure at 10 μg/kg disrupted the development of the fetal mouse prostate.[79] A 2006 study in rats has shown that neonatal bisphenol A exposure at 10 μg/kg levels increases prostate gland susceptibility to adult-onset precancerous lesions and hormonal carcinogenesis.[80] A 2007 in vitro study has found that BPA within the range of concentrations currently measured in human serum is associated with permanently increase in prostate size.[81] A 2009 study has found that newborn rats exposed to a low-dose of BPA (10 µg/kg) increased prostate cancer susceptibility when adults.[82]

[edit]DNA methylation

Bisphenol A suppresses DNA methylation[83] which is linked to epigenetic changes.[84]

[edit]Reproductive system and sexual behavior research

A 2007 study using pregnant mice showed that BPA changes the expression of key developmental genes that form the uterus which may impact female reproductive tract development and the future fertility of female fetuses the mother is carrying.[85]

A series of studies made in 2009 found:

  • Mouse ovary anomalies from exposure as low as 1 µg/kg, concluded that BPA exposure causes long-term adverse reproductive and carcinogenic effects if exposure occurs during prenatal critical periods of differentiation.[86]
  • Neonatal exposure of as low as 50 µg/kg disrupts ovarian development in mice.[87][88][89]
  • Neonatal BPA exposition of as low as 50 µg/kg permanently alters the hypothalamic estrogen-dependent mechanisms that govern sexual behavior in the adult female rat.[90]
  • Prenatal exposure to BPA at levels of (10 μg/kg/day) affects behavioral sexual differentiation in male monkeys.[91]
  • In placental JEG3 cells in vitro BPA may reduce estrogen synthesis.[92]
  • BPA exposure disrupted the blood-testis barrier when administered to immature, but not to adult, rats.[93]
  • Exposure to BPA in the workplace was associated with self-reported adult male sexual dysfunction.[94]

A 2009 rodent study, funded by EPA and conducted by some of its scientists, concluded that, compared with ethinyl estradiol, low-dose exposures of bisphenol A (BPA) showed no effects on several reproductive functions and behavioral activities measured in female rats.[95] That study was criticized as flawed for using polycarbonate cages in the experiment (since polycarbonate contains BPA) and the claimed resistance of the rats to estradiol,[96] but that claim was contested by the authors and others.[97]Another 2009 rodent study found that BPA exposure during pregnancy has a lasting effect on one of the genes that is responsible for uterine development and subsequent fertility in both mice and humans (HOXA10). The authors concluded, "We don't know what a safe level of BPA is, so pregnant women should avoid BPA exposure."[98]

In a 2010 study mice were given BPA at doses thought to be equivalent to levels currently being experienced by humans. The research showed that BPA exposure affects the earliest stages of egg production in the ovaries of the developing mouse fetuses, thus suggesting that the next generation may suffer genetic defects in such biological processes as mitosis and DNA replication. In addition, the research team noted that their study "revealed a striking down-regulation of mitotic/cell cycle genes, raising the possibility that BPA exposure immediately before meiotic entry might act to shorten the reproductive lifespan of the female" by reducing the total pool of fetal oocytes.[99]Another 2010 study with mice concluded that BPA exposure in utero leads to permanent DNA alterations in sensitivity to estrogen.[100] Also in 2010, a rodent study found that by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses, BPA exposure permanently affected the uterus by decreasing regulation of gene expression. The changes caused the mice to over-respond to estrogen throughout adulthood, long after the BPA exposure, thus suggesting that early exposure to BPA genetically "programmed" the uterus to be hyper-responsive to estrogen. Extreme estrogen sensitivity can lead to fertility problems, advanced puberty, altered mammary development and reproductive function, as well as a variety of hormone-related cancers. One of the authors concluded that BPA may be similar to diethylstilbestrol caused birth defects and cancers in young women whose mothers were given the drug during pregnancy.[101]

A 2011 study using the rhesus monkey, a species that is very similar to humans in regard to pregnancy and fetal development, found that prenatal exposure to BPA causes changes in female primates' uterus development.[102] A 2011 rodent study found that male rats exposed to BPA had lower sperm counts and testosterone levels than those of unexposed males.[103] A 2011 mice study found that male mice exposed to BPA became demasculinized and behaved more like females in their spatial navigational abilities. They were also less desirable to female mice.[104]

[edit]General research

At an Endocrine Society meeting in 2009, new research reported data from animals experimentally treated with BPA.[105] Studies presented at the group's annual meeting show BPA can affect the hearts of women, can permanently damage the DNA of mice, and appear to be entering the human body from a variety of unknown sources.[106]

A 2009 in vitro study on cytotrophoblasts cells has found cytoxic effects in exposure of BPA doses from 0.0002 to 0.2 micrograms per millilitre and concluded this finding "suggests that exposure of placental cells to low doses of BPA may cause detrimental effects, leading in vivo to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, prematurity and pregnancy loss"[107]

A 2009 study in rats concluded that BPA, at the reference safe limit for human exposure, was found to impact intestinal permeability and may represent a risk factor in female offspring for developing severe colonic inflammation in adulthood.[108]

A 2010 study on mice has concluded that perinatal exposure to 10 micrograms/mL of BPA in drinking water enhances allergic sensitization and bronchial inflammation and responsiveness in an animal model of asthma,[109]and a 2011 study found that higher BPA concentrations in the urine of the pregnant women at 16 weeks were associated with wheezing, a symptom of asthma, in their babies.[110]

[edit]Studies on humans

[edit]Lang study and heart disease

The first large study of health effects on humans associated with bisphenol A exposure was published in September 2008 by Iain Lang and colleagues in the Journal of the American Medical Association.[111][112] The cross-sectional study of almost 1,500 people assessed exposure to bisphenol A by looking at levels of the chemical in urine. The authors found that higher bisphenol A levels were significantly associated with heart diseasediabetes, and abnormally high levels of certain liver enzymes. An editorial in the same issue concludes:

"Based on this background information, the study by Lang et al,1​ while preliminary with regard to these diseases in humans, should spur US regulatory agencies to follow the recent action taken by Canadian regulatory agencies, which have declared BPA a “toxic chemical” requiring aggressive action to limit human and environmental exposures.4 Alternatively, Congressional action could follow the precedent set with the recent passage of federal legislation designed to limit exposures to another family of compounds, phthalates, also used in plastic. Like BPA,5​ phthalates are detectable in virtually everyone in the United States.6 This bill moves US policy closer to the European model, in which industry must provide data on the safety of a chemical before it can be used in products."[30][113]

A later similar study performed by the same group of scientists, published in January 2010, confirmed, despite of lower concentrations of BPA in the second study sample, an associated increased risk for heart disease but not for diabetes or liver enzymes. Patients with the highest levels of BPA in their urine carried a 33% increased risk of coronary heart disease.[114]

[edit]Other studies

Studies have associated recurrent miscarriage with BPA serum concentrations,[115] oxidative stress and inflammation in postmenopausal women with urinary concentrations,[116] externalizing behaviors in two-year old children, especially among female children, with mother's urinary concentrations,[117] altered hormone levels in men[118][119] and declining male sexual function[120] with urinary concentrations. The Canadian Health Measures Survey, 2007 to 2009 published in 2010 found that teenagers carry 30 percent more l bisphenol A (BPA) in their bodies than older adults. The reason for this is not known.[121] A 2010 study that analyzed BPA urinary concentrations has concluded that for people under 18 years of age BPA may negatively impact human immune function.[122] A study done in 2010 reported the daily excretion levels of BPA among European adults in a large-scale and high-quality population-based sample, and it was shown that higher BPA daily excretion was associated with an increase in serum total testosterone concentration in men.[123] A 2011 study found higher BPA levels in women with polycystic ovary syndrome compared to controls. Furthermore, researchers found a statistically significant positive association between male sex hormones and BPA in these women suggesting a potential role of BPA in ovarian dysfunction.[124] A 2010 study found that people over age 18 with higher levels of BPA exposure had higher CMV antibody levels, which suggests their cell-mediated immune system may not be functioning properly.[125]

[edit]Sexual difficulties

A 2009 study on Chinese workers in BPA factories found that workers were four times more likely to report erectile dysfunction, reduced sexual desire and overall dissatisfaction with their sex life than workers with no heightened BPA exposure.[126] BPA workers were also seven times more likely to have ejaculation difficulties. They were also more likely to report reduced sexual function within one year of beginning employment at the factory, and the higher the exposure, the more likely they were to have sexual difficulties.[127]

[edit]Historical studies

The first evidence of the estrogenicity of bisphenol A came from experiments on rats conducted in the 1930s,[128][129] but it was not until 1997 that adverse effects of low-dose exposure on laboratory animals were first reported.[18]

[edit]Low-dose exposure in animals

Dose (µg/kg/day)Effects (measured in studies of mice or rats,
descriptions (in quotes) are from Environmental Working Group)[130][131]
Study Year
0.025 "Permanent changes to genital tract" 2005[132]
0.025 "Changes in breast tissue that predispose cells to hormones and carcinogens" 2005[133]
1 long-term adverse reproductive and carcinogenic effects 2009[86]
2 "increased prostate weight 30%" 1997[134]
2 "lower bodyweight, increase of anogenital distance in both genders, signs of early puberty and longer estrus." 2002[135]
2.4 "Decline in testicular testosterone" 2004[136]
2.5 "Breast cells predisposed to cancer" 2007[137]
10 "Prostate cells more sensitive to hormones and cancer" 2006[138]
10 "Decreased maternal behaviors" 2002[139]
30 "Reversed the normal sex differences in brain structure and behavior" 2003[140]
50 Adverse neurological effects occur in non-human primates 2008[55]
50 Disrupts ovarian development 2009[87]

The current U.S. human exposure limit set by the EPA is 50 µg/kg/day.[141]

 

[edit]Xenoestrogen

There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to estrogen-related receptor γ (ERR-γ).[142] This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor(ER).[142] BPA binding to ERR-γ preserves its basal constitutive activity.[142] It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.[142]

Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol accumulation in this tissue.[143]

[edit]Human exposure sources

The problem is, BPA is also a synthetic estrogen, and plastics with BPA can break down, especially when they're washed, heated or stressed, allowing the chemical to leach into food and water and then enter the human body. That happens to nearly all of us; the CDC has found BPA in the urine of 93% of surveyed Americans over the age of 6. If you don't have BPA in your body, you're not living in the modern world.

The Perils of PlasticTIME Magazine[144]

Bisphenol A has been known to be leached from the plastic lining of canned foods[145] and polycarbonateplastics, especially those that are cleaned with harsh detergents or those which contain acidic or high-temperature liquids. BPA is an ingredient in the internal coating of metal food and beverage cans used to protect the food from direct contact with the can. A recent Health Canada study found that the majority of canned soft drinks it tested had low, but measurable levels of bisphenol A.[146] Furthermore, A study conducted by the University of Texas School of Public Health in 2010, found BPA in 63 of 105 samples of fresh and canned foods, foods sold in plastic packaging, and in cat and dog foods in cans and plastic packaging. This included fresh turkey, canned green beans, and canned infant formula. [147] While most human exposure is through diet, exposure can also occur through air and through skin absorption.[148]

A 2011 study published in Environmental Health Perspectives, “Food Packaging and Bisphenol A and Bis(2-Ethyhexyl) Phthalate Exposure: Findings from a Dietary Intervention," selected 20 participants based on their self-reported use of canned and packaged foods to study BPA. Participants ate their usual diets, followed by three days of consuming foods that were not canned or packaged. The study's findings include: 1) evidence of BPA in participants’ urine decreased by 50% to 70% during the period of eating fresh foods; and 2), participants’ reports of their food practices suggested that consumption of canned foods and beverages and restaurant meals were the most likely sources of exposure to BPA in their usual diets. The researchers note that, even beyond these 20 participants, BPA exposure is widespread, with detectable levels in urine samples in more than an estimated 90% of the U.S. population.[149]

Free BPA is found in high concentration in thermal paper and carbonless copy paper, which would be expected to be more available for exposure than BPA bound into resin or plastic.[24][150][151] Popular uses of thermal paper include receipts, event and cinema tickets, labels, and airline tickets. A Swiss study found that 11 of 13 thermal printing papers contained 8 - 17 g/kg Bisphenol A (BPA). Upon dry finger contact with a thermal paper receipt, roughly 1 μg BPA (0.2 – 6 μg) was transferred to the forefinger and the middle finger. For wet or greasy fingers approximately 10 times more was transferred. Extraction of BPA from the fingers was possible up to 2 hours after exposure.[152]While there is little concern for dermal absorption of BPA, free BPA can readily be transferred to skin and residues on hands can be ingested.[8]

Studies conducted by the CDC found bisphenol A in the urine of 95% of adults sampled in 1988–1994[153] and in 93% of children and adults tested in 2003–04.[154] While the EPA considers exposures up to 50 µg/kg/day to be safe, the most sensitive animal studies show effects at much lower doses.[130][155]

In 2009, a study found that drinking from polycarbonate bottles increased urinary bisphenol A levels by two thirds, from 1.2 micrograms/gram creatinine to 2 micrograms/gram creatinine.[156] Consumer groups recommend that people wishing to lower their exposure to bisphenol A avoid canned food and polycarbonate plastic containers (which shares resin identification code 7 with many other plastics) unless the packaging indicates the plastic is bisphenol A-free.[157] In order to avoid the possibility of BPA leaching into food or drink, the National Toxicology Panel recommends avoiding microwaving food in plastic containers, putting plastics in the dishwasher, or using harsh detergents.[158] In the U.S., consumption of soda, school lunches, and meals prepared outside the home was statistically significantly associated with higher urinary BPA.[159]

BPA is also used to form epoxy resin coating of water pipes. In older buildings, such resin coatings are used to avoid replacement of deteriorating hot and cold water pipes.[160]

[edit]Fetal and Early Childhood Exposures

Children may be more susceptible to BPA exposure than adults. A recent study found higher urinary concentrations in young children than in adults under typical exposure scenarios.[161] This increased susceptibility is most likely based on their reduced capacity to eliminate xenobiotics[162] and also their estimated higher daily exposure to BPA, adjusted for weight, compared to adults.[163]

Infants fed with liquid formula are among the most exposed, and those fed formula from polycarbonate bottles can consume up to 13 micrograms of bisphenol A per kg of body weight per day (μg/kg/day; see table below).[164] In the US and Canada, BPA has been found in infant liquid formula in concentrations varying from 0.48 to 11 ng/g.[165][166] BPA has been rarely found in infant powder formula (only 1 of 14).[165] While breast milk is the optimal source of nutrition for infants, it is not always an option. The U.S. Department of Health & Human Services (HHS) states that "the benefit of a stable source of good nutrition from infant formula and food outweighs the potential risk of BPA exposure.".[167]

A 2010 study of people in Austria, Switzerland, and Germany has suggested polycarbonate (PC) baby bottles as the most prominent role of exposure for infants, and canned food for adults and teenagers.[168] In the United States, the growing concern over BPA exposure in infants in recent years has lead the manufacturers of plastic baby bottles to stop using BPA in their bottles. However, babies may still be exposed if they are fed with old or hand-me-down bottles bought before the companies stopped using BPA.

One often overlooked source of exposure occurs when a pregnant woman is exposed, thereby exposing the fetus. Animal studies have shown that BPA can be found in both the placenta and the amniotic fluid of pregnant mice. [169] A small US study in 2009, funded by the EWG, detected an average of 2.8 ng/mL BPA in the blood of 9 out of the 10 umbilical cords tested.[170] After the baby is born, maternal exposure can continue to effect the infant through transfer of BPA to the infant via breast milk. [171][172]Because of these exposures that can occur both during and after pregnancy, mothers wishing to limit their child’s exposure to BPA should attempt to limit their own exposures during that time period.

While the majority of exposures have been shown to come through the diet, accidental ingestion can also be considered a source of exposure. One study conducted in Japan tested plastic baby books to look for possible leaching into saliva when babies chew on them. [173] While the results of this study have yet to be replicated, it gives reason to question whether exposure can also occur in infants through ingestion by chewing on certain books or toys.

 

PopulationEstimated daily bisphenol A intake, μg/kg/day.
Table adapted from the National Toxicology Program Expert Panel Report.
Infant (0–6 months)
formula-fed
1–24
Infant (0–6 months)
breast-fed
0.2–1
Infant (6–12 months) 1.65–13
Child (1.5–6 years) 0.043–14.7
Adult 0.008–1.5

[edit]Pharmacokinetics

There is no agreement between scientists of a physiologically-based pharmacokinetic (PBPK) BPA model for humans. The effects of BPA on an organism depend on how much free BPA is available and for how long cells are exposed to it. Glucuronidation in the liver, by conjugation with glucuronic acid to form the metabolite BPA-glucuronide (BPAG),[8] reduces the amount of free BPA, however BPAG can be deconjugated by beta-glucuronidase, an enzyme present in high concentration in placenta and other tissues.[174][175] Free BPA can also be inactivated by sulfation, a process that can also be reverted by arylsulfatase C.[174] A 2010 vitro study has shown that placenta P-glycoprotein may efflux BPA from placenta.[176]

The best test methods for studying BPA effects are currently under discussion with scientists sharing different opinions.[177]

A 2010 review of 80+ biomonitoring studies concluded that the general population is internally exposed to significant amounts of unconjugated BPA (in the ng/ml blood range).[178] Using GC/MS on 20 samples, BPA was detected in 100% of urine samples with a median of 1.25 ng/ml, and 10% of blood samples (LOD 0.5 ng/ml).[179]

A 2009 research has found that some drugs, like naproxensalicylic acidcarbamazepine and mefenamic acid can, in vitro, significantly inhibit BPA glucuronidation.[180]

A 2010 study on rats embryos has found that genistein may enhance developmental toxicity of BPA.[181]

[edit]Environmental risk

In general, studies have shown that BPA can affect growth, reproduction and development in aquatic organisms. Among freshwater organisms, fish appear to be the most sensitive species. Evidence of endocrine-related effects in fish, aquatic invertebrates, amphibians and reptiles has been reported at environmentally relevant exposure levels lower than those required for acute toxicity. There is a widespread variation in reported values for endocrine-related effects, but many fall in the range of 1μg/L to 1 mg/L.[8]

BPA can contaminate the environment either directly or through degradation of products containing BPA, such as ocean-borne plastic trash.[182]

As an environmental contaminant this compound interferes with nitrogen fixation at the roots of leguminous plants associated with the bacterial symbiont Sinorhizobium meliloti. Despite a half-life in the soil of only 1–10 days, its ubiquity makes it an important pollutant.[183] According to Environment Canada, "initial assessment shows that at low levels, bisphenol A can harm fish and organisms over time. Studies also indicate that it can currently be found in municipal wastewater."[184]

A 2009 review of the biological impacts of plasticizers on wildlife published by the Royal Society with a focus on annelids (both aquatic and terrestrial), molluscs,crustaceans, insects, fish and amphibians concluded that BPA have been shown to affect reproduction in all studied animal groups, to impair development in crustaceans and amphibians and to induce genetic aberrations.[185]

A large 2010 study of two rivers in Canada found that areas contaminated with hormone-like chemicals including bisphenol A showed females made up 85 per cent of the population of a certain fish, while females made up only 55 per cent in uncontaminated areas.[186]

[edit]

Sassy releases new list of BPA-containing productsThe items above were previously reported by Sassy to be free of the potentially harmful chemical Bisphenol-A. The company has now revealed that these products do contain BPA.

THIS IS NOT A JOKE!

 

 

 

After readers alerted us to instances where we had listed Sassy products as containing BPA where other online retailers and informational sites listed them as BPA-free, we asked the company to dig deeper to provide us with a comprehensive list that could clear up the discrepancies. Three months later, we received a materials list from the company's R&D group that corrects information previously provided by customer service representatives and Sassy managers in more than a dozen cases. Sadly, ten of these cases are of products previously stated to be BPA-free, which the company now states do contain Bisphenol-A, many of them using it in conjunction with color-changing properties.

The following items were previously reported by Sassy as BPA-free, but are now reported to contain BPA:

Feeding products

  • Snack Time Infa-Trainer Cup

  • Color Change Fork and Spoon

  • Color Change Infant Feeding Spoon

  • Extra Gentle Soft Tip Spoon

  • Flexi Grip Toddler Spoon and Fork

  • Ideal Temp Feeding Spoon

  • EZ Grip Feeding Bowls with utensils


Bath Toys

  • Soft Ducky

  • Squirting Sea Pals

  • Boogie Board Buddy


They are attacking are kids and us please watch out for this toxin!!